NIH-NCATS-20004221 – Sources Sought – Regis Technologies (R,R) Whelk-O 1, 500 mm x 50 mm, 16 μm preparative column

Sep 2, 2020 | Sources Sought

Federal Business Opportunities (FBO)


1. Solicitation Number: NIH-NCATS-20004221

2. Title: Regis Technologies (R,R) Whelk-O 1, 500 mm x 50 mm, 16 μm preparative column

3. Classification Code: 66 — Instruments & laboratory equipment

4. NAICS Code: 325411 – Medicinal and Botanical Manufacturing

5. Description:

This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement.

This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only.

Background: The National Center for Advancing Translational Sciences (NCATS) within the National Institutes of Health (NIH) has a mission to catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions. To this end, DPI maintains a library of >400,000 compounds, which is used in high-throughput biological screening assays focusing on various protein targets and disease states. DPI medicinal chemists are synthesizing thousands of compounds each year to add to the NCATS collection. Increasingly, these compounds contain chiral centers that significantly affects the 3D structure and how the compounds interact with a target. The determination of stereochemistry within a compound is critical for the development of small molecule therapeutics as structure is highly involved in a drug’s activity. Separation and isolation of chiral compounds with high enantiomeric purity is of great importance.

The chemical and enantiomeric purity of chiral compounds is routinely determined within the Analytical Chemistry group’s full scale chiral laboratory. Methods development with the chiral chromatography screening protocol involves the utilization of various chiral stationary phases in conjunction with multiple mobile phase conditions. Once optimal

separation conditions are determined sample purification on a scale of up to hundreds of milligrams is possible. However, with the compounds synthesized by the medicinal chemists possessing diverse chemotypes, current columns cannot adequately separate the chiral material. As such, we require new specialized semi-preparative columns to expand our chiral purification capabilities. Without the Regis Technologies (R,R) Whelk-O 1, 500 mm x 50 mm, 16 μm preparative column, productivity and efficiency will be lost as we will have to contract out the work, which can be costly and cause significant delays.

Purpose: This is to purchase a Regis Technologies (R,R) Whelk-O 1, 500 mm x 50 mm, 16 μm preparative column for use by the Analytical Chemistry group within the Division of Pre-Clinical Innovation (DPI) at NCATS.

Generic Name of Product: Regis Technologies (R,R) Whelk-O 1, 500 mm x 50 mm, 16 μm preparative column

Anticipated Period of Performance: Within 30 days after receipt of award

Capability statement /information sought: Contractors that believe that they possess the ability to provide the required equipment, should submit documentation on their ability to meet each of the project requirements to the Contract Specialist.

The Contractor should directly and specifically state in the, capabilities statement, which project requirements can be meet and/or supplied. The Contractor must also provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, GSA number (If available) etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements.

The information submitted must be must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required.

The response is limited to two (2) page limit. The 2-page limit does not include the cover page or executive summary.

The response must include the respondents’ technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses.

All responses to this notice must be submitted electronically to the Contract Specialist. Facsimile responses are NOT accepted.

The response must be submitted to Thien Nguyen, Contract Specialist, at

The response must be received on or before September 10, 2020 at 12 pm, Eastern Time.

Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work.

Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation.

Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).

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