75N95021Q00231 – Sources Sought – Fibrosis markers in kidney disease associated with dementia

Jun 17, 2021 | Sources Sought

  1. This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice.

This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition.  It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract.  Responses will not be considered as proposals or quotes.  No award will be made as a result of this notice.  The Government will NOT be responsible for any costs incurred by the respondents to this notice.  This notice is strictly for research and information purposes only.

Background:  The prevalence of chronic kidney disease (CKD) and cognitive impairment (CI) increases with age. CKD is a significant risk factor in the development of CI. CKD is greater in females vs. males due to a higher risk of renal infections and a decline of protective hormones with age.

Cardiovascular diseases (CVD) and increased central arterial stiffness (CAS) accompany development of CKD and CI. The markers of CVD and CKD, specifically Angiotensin II, aldosterone, MBG, brain natriuretic peptide (BNP), transforming growth factor beta 1 (TGF-beta1), amyloid beta, paraoxonase (PONs), and the pro-thrombosis factors, can be measured in urine, plasma and tissues. The animal models of CKD are accompanied by increased risk of thrombosis, bleeding and susceptibility to venous thromboembolism, which contribute to the development of CI. Females may have a higher risk of CVD-CKD-CI development. CKD, CAS and CVD may potentiate the development of CI.

The Study Objectives are to determine whether CKD potentiates development of CI due to CAS and whether the CAS markers levels increase in CKD.

Purpose and Objectives: The contractor shall develop the animal models of chronic kidney disease (CKD). These models include partial nephrectomy (PNX) model and non-surgical dietary model, accompanied by fibrosis, thrombosis and/or by changes in paraoxonases (PONs; the enzymes, responsible for the utilization of the steroids).

Project requirements:  Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the Statement of Work attached to this Sources Sought notice.

Anticipated period of performance: The anticipated period of performance is six (6) months from date of award.

Capability statement /information sought.

Respondents must provide, as part of their response, a capability statement that clearly identifies information regarding: (a) staff expertise, including their availability, experience, and formal and other training; (b) current in-house capability and capacity to perform the work; (c) prior completed projects of similar nature; (d) corporate experience and management capability; and (e) examples of prior completed Government contracts, references, and other related information.

Please note that NIA is particularly interested in small business sources. If you are a small business, please state the type of small business (small business; HUBZone; service-disabled, veteran-owned; 8(a); veteran-owned; woman-owned; or small disadvantaged businesses) and your size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible.

The respondent must also provide their  DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements.

One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2” x 11” paper size, with 1” top, bottom, left and right margins, and with single or double spacing.

The information submitted must be in an outline format that addresses each of the elements of the project requirements and in the capability statement /information sought paragraphs stated herein.  A cover page and an executive summary may be included but is not required.

The response is limited to ten (10) pages.  The 10-page limit does not include the cover page, executive summary, or references, if requested.

The response must include the respondents’ technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses.

All responses to this notice must be submitted electronically to the Contract Specialist.  Facsimile responses are NOT accepted.

The response must be submitted to Jeanette Russell, Contract Specialist, at e-mail address Jeanette.Russell@nih.gov.

The response must be received on or before July 1, 2021 at 10:00 am, Eastern Time.

Disclaimer and Important Notes:  This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work.

Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in SAM.gov. However, responses to this notice will not be considered adequate responses to a solicitation.

Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).”

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