75N95020Q00283 – Sources Sought – Brain Slice Electrophysiology Rig

Aug 26, 2020 | Sources Sought

Federal Business Opportunities (FBO)


  1. Solicitation Number: 75N95020Q00283
  2. Title:  Brain Slice Electrophysiology Rig
  3. Classification Code: 6640 (LABORATORY EQUIPMENT AND SUPPLIES)
  4. NAICS Code: 541330
  5. Description: 

This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice.

This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition.  It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract.  Responses will not be considered as proposals or quotes.  No award will be made as a result of this notice.  The Government will NOT be responsible for any costs incurred by the respondents to this notice.  This notice is strictly for research and information purposes only.

Background:  The Neuronal Circuits and Behavior Unit (NCBU) of the Cellular Neurobiology Research Branch (CNRB), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), uses a combination of state-of-the-art optogenetic, electrophysiology, two-photon fluorescence endomicroscopy, immunohistochemistry, and behavioral assays to elucidate the neuronal basis of survival behaviors, such as feeding, and determine how these behaviors are disrupted in eating disorders and drug addiction.

Attached-captioned Doric Lenses Inc. items are for Dr. Aponte’ s lab, which is applying molecular biology, behavioral assays, brain slice electrophysiology and in vivo endomicroscopy methods to molecularly-defined neuron populations.  Each specific line item in the attached quotes has been thoroughly considered and found necessary by Dr. Aponte for her experiments. The Aponte lab requests a brain slice electrophysiology rig to accommodate ongoing experiments with animal models involved in the study of motivation and reward-responses, animal models of pain, such as neuropathic, visceral, and inflammatory, with and without opioid administration, animal models assessing consummatory and appetitive feeding behaviors, animal models assessing risk-taking behaviors, and animal models of addiction-related behaviors exhibited during opioid taking and withdrawal from drugs of abuse.

Purpose and Objectives: NCBU requires an instrument with the following characteristics:

  1. Slicescope Pro 6000 with Two PatchStars             
  2. Dovetail Probe Holder
  3. Electrobe Holding Bar
  4. LinLab II and Product Manuals USB
  5. 780nm LED System for SliceScope
  6. Contrast Tube
  7. Condenser Cover
  8. Condenser
  9. Immersion Oil 8cc
  10. Motorised Objective Changer (MOC)
  11. 4x Objective
  12. 40x Water Immersion Objective
  13.  SliceScope Fluroscence Adapter Kit
  14. Fluroscence Turret
  15. mCherry/ Texas Red Filter Set
  16. GFP Filter Set
  17. ET Cy5 Filter Set
  18. pE-300 Ultra LLG Delivery  
  19. Imaging Lens Package
  20. Prime BSI Express
  21. Multiclamp 700B
  22. Digidata 1550B0Low-Noise Data Acquisition System
  23. Electrophysiology software (Windows)
  24. Temperature Controller with Peltier Heater
  25. 120S/DM3 Pump
  26. Tygon Green/Green Tubing
    Quantity: (1) of each of the items

Delivery Date: 8-10 weeks from date of award

Delivery made to the following address:

NIH/NIDA Intramural Research Program

251 Bayview Blvd, Suite 200, Room 06A705

Baltimore, MD 21224

443-740-2476 (tel)

Warranty: Full warranty to include one year full parts and labor. Warranty to commence after installation and instrument is up and running properly.

Capability statement /information sought:

Respondents must provide clear and convincing documentation of their capability of providing the products specificed in this notice. Also, information must be provided in sufficient details of the respondents’ (a) staff expertise, including their availability, experience, formal and other training; (b) current in-house capability to perform the work; (c) prior completed projects of similar nature; (d) corporate experience and other management capability; and (e) examples of prior completed Government contracts, references, and other related information.

The respondent must also provide their  DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements.

Finally, respondents are also encouraged to provide a general overview of the respondent’s opinions about the difficulty and/or feasibility of the potential requirement, and any other information regarding innovative ideas or concepts that may be applicable.

Submission Instructions:

One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2” x 11” paper size, with 1” top, bottom, left and right margins, and with single or double spacing.

The information submitted must be must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein.  A cover page and an executive summary may be included but is not required.

The response is limited to ten (10) page limit.  The 10-page limit does not include the cover page, executive summary, or references, if requested.

The response must include the respondents’ technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses.

All responses to this notice must be submitted electronically to the Contract Specialist and Contracting Officer.  Facsimile responses are NOT accepted.

The response must be submitted to Scott Duernberger, Contracting Specialist, NIH/NIDA at scott.duernberger@nih.gov and Tracy Cain, Contracting Officer, NIH/NIDA at tracy.cain@nih.gov.  

The response must be received on or before August 31, 2020 at 12:00PM Eastern Time.

 Disclaimer and Important Notes:  This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work.

Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation.

Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).”

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